DIFFERENCES OF HOMEOSTASIS MODEL ASSESMENT-INSULIN RESISTANCE (HOMA-IR) LEVELS BETWEEN OBESITY PREGNANT WOMEN WITH THE NORMAL WEIGHT IN PREECLAMSIA

Abstract

Preeclampsia  is a leading cause of maternal death. Maternal factors are the originators of late onset preeclampsia (LOP). One maternal factor is HOMA-IR that is associated with inflammation and insulin resistance. This study aims to determine differences in the mean maternal HOMA-IR levels between obese pregnant women and those who have normal weight in the Late Onset Preeclampsia.This study design is Comparative cross sectional, the study was conducted at Dr. M. Djamil Hospital, The Biochemistry Laboratory and the Biomedical Laboratory of the Faculty of Medicine, Andalas University, Padang in February 2016 - January 2017. The number of samples was 40 selected by consecutive sampling, which were divided into 2 groups: 20 obese respondents and 20 normal weight respondents. Resistin levels were examined by the ELISA method, then data were analyzed by the mann-whitney test.The results of the study showed that the median HOMA-IR level in the obese group was  1,291 (0,409 – 17,308) µU/ml dan mmol/L and the median normal weight group was 0,139 (0,004 – 0,370) µU/ml dan mmol/L. Statistically obtained p value <0.001 means that there is a significant difference between levels of HOMA-IR in obesity and normal weight. In conclusion, the median level of HOMA-IR was higher in the obese group than in the normal weight group. There is a significant difference between HOMA-IR  levels in obesity and normal weight